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is not yet present. The // classes are added to so styling immediately reflects the current // toolbar state. The classes are removed after the toolbar completes // initialization. const classesToAdd = ['toolbar-loading', 'toolbar-anti-flicker']; if (toolbarState) { const { orientation, hasActiveTab, isFixed, activeTray, activeTabId, isOriented, userButtonMinWidth } = toolbarState; classesToAdd.push( orientation ? `toolbar-` + orientation + `` : 'toolbar-horizontal', ); if (hasActiveTab !== false) { classesToAdd.push('toolbar-tray-open'); } if (isFixed) { classesToAdd.push('toolbar-fixed'); } if (isOriented) { classesToAdd.push('toolbar-oriented'); } if (activeTray) { // These styles are added so the active tab/tray styles are present // immediately instead of "flickering" on as the toolbar initializes. In // instances where a tray is lazy loaded, these styles facilitate the // lazy loaded tray appearing gracefully and without reflow. const styleContent = ` .toolbar-loading #` + activeTabId + ` { background-image: linear-gradient(rgba(255, 255, 255, 0.25) 20%, transparent 200%); } .toolbar-loading #` + activeTabId + `-tray { display: block; box-shadow: -1px 0 5px 2px rgb(0 0 0 / 33%); border-right: 1px solid #aaa; background-color: #f5f5f5; z-index: 0; } .toolbar-loading.toolbar-vertical.toolbar-tray-open #` + activeTabId + `-tray { width: 15rem; height: 100vh; } .toolbar-loading.toolbar-horizontal :not(#` + activeTray + `) > .toolbar-lining {opacity: 0}`; const style = document.createElement('style'); style.textContent = styleContent; style.setAttribute('data-toolbar-anti-flicker-loading', true); document.querySelector('head').appendChild(style); if (userButtonMinWidth) { const userButtonStyle = document.createElement('style'); userButtonStyle.textContent = `#toolbar-item-user {min-width: ` + userButtonMinWidth +`px;}` document.querySelector('head').appendChild(userButtonStyle); } } } document.querySelector('html').classList.add(...classesToAdd); })(); Anding Shen | Â鶹Çø

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Dr. Anding Shen

Professor
Biology

Biography

I am a member of Madison Square Christian Reformed Church and the Grand Rapids Chinese Christian church. I enjoy music and worship, traveling, photography, and playing volleyball and tennis.

Education

  • Ph.D., John Hopkins University (2004)
  • B.S., Drexel University (1998)

Professional Experience

  • Â鶹Çø, Professor of Biology (2018–present)
  • Calvin College, Associate Professor of Biology (2011–2018)
  • Calvin College, Assistant Professor of Biology (2005–2011)
  • Washington Bible College, Adjunct Professor of Biology (2005)
  • Johns Hopkins University, Post-Doctoral Fellow (2004–2005)
  • McNeil Consumer Product Company, Research Intern (1995–1996)
  • SmithKline Beecham Pharmaceuticals, Research Assistant (1994–1995)

Academic Interests

  • T cell immunology
  • Traditional Chinese Medicine

Research

My ongoing research studies latent reservoirs of HIV infection. I am investigating the mechanisms of how reservoirs are formed and potential ways to remove the latent reservoir. My latest work involves investigating the roles of endothelial cells in HIV infection and latency in resting CD4+ T cells.

  • HIV as a Latent Reservoir in Resting T Helper Cells.
  • Investigating the Roles of Endothelial Cells on HIV Infection.

Visit this faculty profile for more information. 

Research and Scholarship

HIV(2)

HIV as a Latent Reservoir in Resting T Helper Cells

Currently, HIV latency is the most significant problem preventing a cure for AIDS. In this study, a replication incompetent pseudotyped virus system is used to investigate how endothelial cells interact with resting T helper cells to promote HIV infection and latency formation.

Student Contributors: Tran Nguyen, Abuoma Nwadike, Wei Wang, John Morris, Anne Barron, John Morris, Yelena Boykov, Jake Baker, Geoff Scott
Investigating Roles of Endothelial Cells on HIV Infection(2)

The Roles of Endothelial Cells on HIV Infection

In many patients with HIV-1 infection, highly active antiretroviral therapy (HAART) successfully suppresses viral loads and restores the immune system. However, a major latent reservoir identified in resting T helper cells (a type of white blood cell) poses a great barrier to viral eradication and ensures viral persistence in patients. A more complete understanding of the mechanisms contributing to the establishment of the reservoir will influence the strategies in battling viral persistence. Some recent studies demonstrated that endothelial cells increased the level of HIV infection in resting T helper cells and might play a significant role in latency formation in these cells. In this study, a replication incompetent pseudotyped virus system is used to investigate how endothelial cells interact with resting T helper cells to promote HIV infection and latency formation.
Anding Shen

Contact Me

616-526-6025
209 DeVries Hall

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